Viagra working mechanism

The physiologic mechanism of erection of the penis involves release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood.

Sildenafi

Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by Sildenafil or Kamagra causes increased levels of cGMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at recommended doses has no effect in the absence of sexual stimulation.

viagra-work-pic

Viagra, or Vigora, belongs to the class of PDE5 inhibitor drugs which inhibit or block the chemicals known as phospho diesterase inhibitor drugs, which are used for erectile dysfunction treatment and are in clinical trials for prostate adenoma treatment. The physiology of erections involves many chemical reactions in the body. The sexual stimulation releases nitric oxide in the corpus cavernosum, the two parallel channels situated at the sides along the length of the penis. The release of nitric oxide activates the enzyme guanylate cyclase which results in the increased levels of cyclic guanosine monophosphate responsible for the penile erections.

Levitra in prostatitis treatment

 Levitra (vardenafil HCl) is an FDA-approved oral prescription medication for the treatment of erectile dysfunction (ED) in men. It belongs to a class of drugs called “PDE5 inhibitors.” It works by increasing blood flow to the penis to help improve erectile function. The active ingredient in Levitra works specifically on the chain of events that occurs in the penis during arousal, when two large chambers in a man’s penis fill with blood. Learn More

Viagra working mechanism

Viagra working mechanism is by inhibiting the chemical phosphodiesterase type 5 which is responsible for the erections turning flaccid. This prolongs the effect of the muscle relaxation in the corpus cavernosum area of the penis allowing the blood to flow into the spongy tissues of the penis causing an erection. Viagra does not have any direct relaxant effect on the corpus cavernosum area in the human penis but enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP or cyclic guanosine monophosphate in the corpus cavernosum. When sexual stimulation causes local release of nitric oxide the inhibition of PDE5 by Viagra causes increased levels of cGMP or cyclic guanosine monophosphate in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum resulting in the required erections of the penis.

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